Migraine headaches are quite common, affecting 12% of the worldwide population. Migraine headaches usually start in response to a specific trigger. Usually there is mild pain that gets worse to severe pain, characterized by throbbing or pulsing headache, often affecting one side of the head. Associated symptoms include nausea, vomiting and sensitivity to light and/or sound. Migraine sufferers may feel sensory warning symptoms, called an aura, just before onset of the headaches. Migraines appear to run in families. The mainstay of treatment is a group of drugs called “triptans” which work by blocking the release of pro inflammatory compounds within the brain. They are fairly effective for aborting or lessening harshness of migraine headaches. Unfortunately, negative effects could be significant and can include rebound headaches, pain or chest tightness, dizziness, nausea, vomiting, or warmth, redness, or tingling underneath the skin. Triptans are also costly, and several insurance providers restrict the amount of these medications that may be dispensed to patients. Another group of medicines called ergot alkaloids will also be prescribed for migraines, but they are less efficient than triptans.
Unfortunately, little research exists that proves the mechanism by which cannabinoids alleviate migraines, despite the overwhelming anecdotal reports from patients suffering with them. Recent surveys reveal that migraine headaches might be because of endocannabinoid deficiency and abnormal inflammatory response. Understand that the endocannabinoid system exists to keep cellular homeostasis. Often migraine sufferers report that headaches begin in reaction to some trigger, like bright light, hunger, hormones, or certain smells or foods. The trigger event causes an imbalance in the brain, that ought to then trigger the production of endocannabinoids to maintain homeostasis. If an individual is deficient in endocannabinoids, the imbalance continues, leading to development of the migraine headache. The trigger could also cause inflammation, which can become uncontrollable and contribute to the resulting pain.
The few studies who have looked at the web link between migraines and also the ECS are summarized here:
Endocannabinoids and synthetic cannabinoids inhibited receptors that control vomiting and pain, trying to block these symptoms. THC reduces serotonin release (which blocks vomiting and pain) from your platelets of human migraine sufferers.
Cannabinoids were found to bind to regions of the periaqueductal gray matter (an area of the brain that modulates pain transmission) that have been implicated in migraine generation.Three cases were reported of chronic heavy users of cannabis developing severe migraine attacks after abrupt cessation useful; authors suggested that these particular rebound attacks are similar to similar rebound headaches experienced by migraine patients once they abruptly stop other migraine treatment. Genes that permit for increased inflammation were present in migraine patients and never present in control subjects.
Endocannabinoid levels were decreased in patients with chronic migraine and medication-over-use headaches suggesting that endocannabinoid dysfunction is involved in these two chronic conditions
Cannabis has been utilized for centuries to deal with headaches. Medical cannabis patients have found relief of pain, less nausea, and much better sleep. Patients also report less frequency and much less severity of their migraine headaches with medical cannabis use. Numerous well-known trigger factors for migraine headaches, specifically sleep deprivation and anxiety or stress, are alleviated with cannabis, thereby reducing the amount of migraine attacks. Patients also are convinced that they spend less healthcare dollars on expensive migraine medications, have less missed days at school or at work, and also have overall improved total well being.
There is not any question that THC-rich cannabis may help abort or lessen the severity of a migraine, particularly if taken in the onset of the discomfort. Some patients are convinced that low-dose, regular use of THC-rich medicine significantly reduces frequency and severity of the headaches. Other patients are convinced that daily CBD-rich cannabis prevents migraine from occurring. After the headache begins, a rapid delivery method including inhalation or sublingual tincture is liked by most. Specific strain choice is a result of trial and error for the majority of patients.
Most cannabinoids are classified under schedule 1 of the Federal Controlled Substances Act 1970, in addition to heroin and ecstacy. Hence they can not be prescribed by physicians, and by implication, have zero accepted medical use using a high abuse potential. Despite their legal status, hallucinogens and cannabinoids are utilized by patients for relief of headache, helped from the growing variety of American states which have legalized medical marijuana. Cannabinoids in particular use a long history of utilization in the abortive cuudpe and prophylactic therapy for migraine before prohibition and therefore are still used by patients as a migraine abortive in particular. Most practitioners are unaware of the prominence cannabis or “marijuana” once located in medical practice. Hallucinogens are being increasingly employed by cluster headache patients outside of physician recommendation mainly to abort a cluster period and keep quiescence in which there exists considerable anecdotal success. The legal status of cannabinoids and hallucinogens has for some time severely inhibited scientific research, and there are still no blinded studies on headache subjects, from which we might assess true efficacy.